BC2
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Revision as of 03:16, 28 September 2015 by Miopio (Talk | contribs) (Created page with "==Molecular Definition== File:Cb2gfp_huberman2008.PNG|thumb|right|400px|GFP positive cells in whole mount CB2-GFP mouse retina. A. whole mount retina. Scale = 500um B. GFP...")
Contents
Molecular Definition
GFP positive cells in whole mount CB2-GFP mouse retina. A. whole mount retina. Scale = 500um B. GFP positive cells. C. Alpha RGCs are immunpositive to SMI-32 cells. D. GFP positive cells are all SMI-32 positive. CB2-RGCs appear to be alpha type RGCs. scale = 125um. E. GFP positive cells in the GCL (CB2-RGCs) and INL (amacrine cells). Scale = 100um. Image adapted from Huberman et al., 2008
Physiology
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Anatomy
Dendritic Morphology
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Retinal Input
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Schematic showing circuitry of alpha RGCs in mouse retina. S-pigment dominated cones send inputs to M-cone-dominated hyperpolarizing bipolar cell, which in turn sends its signals to transient alpha RGC. This signal is mediated by amacrine cells with mixed rod-cone inputs. Image adapted from Pang et al., 2003
Central Projections
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Axonal projections of CB2-RGCs to SC. A. Ctb-594 labeling (red) of all RGC axons. B. GFP positive CB2-RGCs (green). C. Merge of both Ctb and GFP. CB2-RGC projections are organized in a highly specific manner. They project exclusively to the lower SGS of the SC, and organize in columnar fashion. Scale = 250um. Image adapted from Huberman et al., 2008
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Axonal projections of CB2-RGCs to dLGN. E. Ctb-594 labeling (red) of all RGC axons. F. GFP positive CB2-RGCs (green). Asterisks mark where axons project through the lateral third of the dLGN to terminate in inner dLGN. G. Merge of both Ctb and GFP positive cells. Scale = 250um. Image adapted from Huberman et al., 2008
Development
Developmental differences of CB2-RGC projections to SC in P4 and P10 mice. B. CB2-RGC projections in P4 mouse show beginnings of laminar and columnar structure, but are relatively nonspecific. E. CB2-RGC projections in P10 mouse exhibit laminar and columnar structure similar to that of the adult mouse. Scale = 250um. Image adapted from Huberman et al., 2008
History
References
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