Difference between revisions of "Retinal Neuron Classification"

From Eyewire
Jump to: navigation, search
(Contribute)
(Marked this version for translation)
 
(14 intermediate revisions by 4 users not shown)
Line 1: Line 1:
 +
__NOTOC__
 
<!--        BANNER ACROSS TOP OF PAGE        -->
 
<!--        BANNER ACROSS TOP OF PAGE        -->
 
{| id="mp-topbanner" style="width:100%; background:#A7E9FF; margin:1.2em 0 6px 0; border:1px solid #A7E9FF;"
 
{| id="mp-topbanner" style="width:100%; background:#A7E9FF; margin:1.2em 0 6px 0; border:1px solid #A7E9FF;"
Line 5: Line 6:
 
{| style="width:300px; border:none; background:none;"
 
{| style="width:300px; border:none; background:none;"
 
| style="width:300px; text-align:center; white-space:nowrap; color:#000;" |
 
| style="width:300px; text-align:center; white-space:nowrap; color:#000;" |
<div style="font-size:200%; border:none; margin:0; padding:.1em; color:#000; align:center">Retinal Neuron Classification</div>
+
<div style="font-size:200%; border:none; margin:0; padding:.1em; color:#000; align:center"><translate><!--T:1-->
 +
Retinal Neuron Classification</translate></div>
 
|}
 
|}
 
<!--        PORTAL LIST ON RIGHT-HAND SIDE        -->
 
<!--        PORTAL LIST ON RIGHT-HAND SIDE        -->
Line 19: Line 21:
 
</table>
 
</table>
 
}}
 
}}
 +
<translate>
 +
<!--T:2-->
 +
To understand how a brain perceives and processes sensory information, many researchers look to the visual system - a system that makes its start with the neurons in the retina. Starting with Ramon y Cajal, large amounts of effort have been devoted to characterizing retinal neurons, in the hope to develop better tools to control and interact with those cells types, and improve models of information processing. [1]
  
Understanding how the brain processes sensory stimuli requires knowledge of the basic building blocks that make up the circuitry of the brain. A prime system to conduct this effort in is the visual system. The neurons within the retina provide the only gateway to the rest of the visual system, arguably making it one of the most accessible sensory systems to study in all species. Researchers have put in an incredible amount of effort in the classification of retinal neurons, both in recent years and back in the time of Ramon y Cajal. The progress that has been made since then is astounding--especially in the mouse retina, in which molecular and genetic methods have allowed for more than half of the retinal neuron types to be definitively classified (Sanes and Masland, 2015). However, abundance of information comes with an increasing necessity for communication among those participating in this endeavor. To effectively conduct future studies, it becomes critical to discern which categorized cell types correspond with each other, and to utilize the entirety of information already available to us about different cell types.
+
<!--T:3-->
 +
Using the mouse as a model organism, there has recently been significant progress in classifying retinal neuron types via molecular and genetic methods; researchers estimate over half of the types have been definitively identified. [2] Combined with the increasing effectiveness of circuit reconstructions, that progress is expected to quicken. To fully harness this fast-growing knowledge base and design effective future studies, it's imperative that researchers are able to quickly find existing cell type information and easily add new findings.  
  
==Our Purpose==
+
<!--T:4-->
 +
Please join us and help the community in this drive to characterize all the retinal neuron types and clarify our understanding of how we see the world.
 +
 
 +
==Our Purpose== <!--T:5-->
 
The goal of this wiki is to consolidate information from existing retinal neuron classifications and accomplish the following:  
 
The goal of this wiki is to consolidate information from existing retinal neuron classifications and accomplish the following:  
 
* To establish a complete and accurate list of retinal neuron types, including synonyms
 
* To establish a complete and accurate list of retinal neuron types, including synonyms
Line 28: Line 37:
 
* To cross-reference with information about cell types generated by EyeWire and showcased in [http://museum.eyewire.org/| Cell Museum]
 
* To cross-reference with information about cell types generated by EyeWire and showcased in [http://museum.eyewire.org/| Cell Museum]
  
==Our Approach==
+
==Our Approach== <!--T:6-->
 
Because there is so much information about so many cell types being generated, a single person cannot document it all.
 
Because there is so much information about so many cell types being generated, a single person cannot document it all.
 
We believe that the wiki must be developed collectively by multiple contributors from the research community.  
 
We believe that the wiki must be developed collectively by multiple contributors from the research community.  
Line 34: Line 43:
 
We hope that this wiki will act as a useful resource for those conducting research in the retina and the rest of the visual system, and help us all in a collective effort to make a complete catalog of murine retinal neurons.
 
We hope that this wiki will act as a useful resource for those conducting research in the retina and the rest of the visual system, and help us all in a collective effort to make a complete catalog of murine retinal neurons.
  
==Contribute==
+
==Contribute== <!--T:7-->
 
The wiki will not succeed without your help. '''If you are interested in contributing, please [http://54.88.64.197/index.php?title=Special:UserLogin&returnto=Main+Page&type=signup create an account] with us and begin editing.'''  
 
The wiki will not succeed without your help. '''If you are interested in contributing, please [http://54.88.64.197/index.php?title=Special:UserLogin&returnto=Main+Page&type=signup create an account] with us and begin editing.'''  
  
Existing pages are listed below in blue, while suggested pages are listed in red. You can also create a new page by typing the title of your new page in the search box, then following the prompts that follow. You can add your new page to the table below by putting your page name in double brackets ('[[xyz]]') in the appropriate slot.
+
<!--T:8-->
 +
Existing pages are listed below in <span style="color:blue;">blue</span>, while suggested pages are listed in <span style="color:red;">red</span>. You can also create a new page by typing the title of your new page in the search box, then following the prompts that follow. You can add your new page to the table below by putting your page name in <code><nowiki>[[double brackets]]</nowiki></code> in the appropriate place in the editing box (click the 'E' on the upper left side of the box to edit). Some useful wiki mark-ups can be found [https://en.wikipedia.org/wiki/Help:Wiki_markup here].
  
 +
<!--T:9-->
 
If you have never edited a wiki before and require assistance, or if you have any suggestions for this wiki, [mailto:makasako@princeton.edu| email us] and we will be glad to help.
 
If you have never edited a wiki before and require assistance, or if you have any suggestions for this wiki, [mailto:makasako@princeton.edu| email us] and we will be glad to help.
  
 +
<!--T:10-->
 
{{Retinal Neuron Types}}
 
{{Retinal Neuron Types}}
  
==References==
+
==References== <!--T:11-->
Sanes JR and Masland RH (2015). The types of retinal ganglion cells: current status and implications for neuronal classification. Annu. Rev. Neurosci. 38, 221-246. [http://www.ncbi.nlm.nih.gov/pubmed/25897874 PubMed]
+
[1] [http://braininitiative.nih.gov/pdf/BRAIN2025_508C.pdf Brain 2025: A Scientific Vision; Goal #1]
 +
 
 +
<!--T:12-->
 +
[2] Sanes JR and Masland RH (2015). The types of retinal ganglion cells: current status and implications for neuronal classification. Annu. Rev. Neurosci. 38, 221-246. [http://www.ncbi.nlm.nih.gov/pubmed/25897874 PubMed]
 +
 
 +
</translate>

Latest revision as of 18:25, 14 June 2016

Retinal Neuron Classification

To understand how a brain perceives and processes sensory information, many researchers look to the visual system - a system that makes its start with the neurons in the retina. Starting with Ramon y Cajal, large amounts of effort have been devoted to characterizing retinal neurons, in the hope to develop better tools to control and interact with those cells types, and improve models of information processing. [1]

Using the mouse as a model organism, there has recently been significant progress in classifying retinal neuron types via molecular and genetic methods; researchers estimate over half of the types have been definitively identified. [2] Combined with the increasing effectiveness of circuit reconstructions, that progress is expected to quicken. To fully harness this fast-growing knowledge base and design effective future studies, it's imperative that researchers are able to quickly find existing cell type information and easily add new findings.

Please join us and help the community in this drive to characterize all the retinal neuron types and clarify our understanding of how we see the world.

Our Purpose

The goal of this wiki is to consolidate information from existing retinal neuron classifications and accomplish the following:

  • To establish a complete and accurate list of retinal neuron types, including synonyms
  • To provide information about each cell type, with links to the relevant literature
  • To cross-reference with information about cell types generated by EyeWire and showcased in Cell Museum

Our Approach

Because there is so much information about so many cell types being generated, a single person cannot document it all. We believe that the wiki must be developed collectively by multiple contributors from the research community. This approach will also keep the information current as new research is published. We hope that this wiki will act as a useful resource for those conducting research in the retina and the rest of the visual system, and help us all in a collective effort to make a complete catalog of murine retinal neurons.

Contribute

The wiki will not succeed without your help. If you are interested in contributing, please create an account with us and begin editing.

Existing pages are listed below in blue, while suggested pages are listed in red. You can also create a new page by typing the title of your new page in the search box, then following the prompts that follow. You can add your new page to the table below by putting your page name in [[double brackets]] in the appropriate place in the editing box (click the 'E' on the upper left side of the box to edit). Some useful wiki mark-ups can be found here.

If you have never edited a wiki before and require assistance, or if you have any suggestions for this wiki, email us and we will be glad to help.

References

[1] Brain 2025: A Scientific Vision; Goal #1

[2] Sanes JR and Masland RH (2015). The types of retinal ganglion cells: current status and implications for neuronal classification. Annu. Rev. Neurosci. 38, 221-246. PubMed