Difference between revisions of "Retinal Neuron Classification"

Revision as of 16:27, 28 September 2015

Understanding how the brain processes sensory stimuli requires knowledge of the basic building blocks that make up the circuitry of the brain. A prime system to conduct this effort in is the visual system. The neurons within the retina provide the only gateway to the rest of the visual system--arguably making it one of the most accessible sensory systems to study in all species. Researchers have put in an incredible amount of effort in the classification of retinal neurons, both in recent years and back in the time of Ramon y Cajal. The progress that has been made since then is astounding--especially in the mouse retina, in which molecular and genetic methods have allowed for more than half of the retinal neuron types to be definitively classified (Sanes and Masland, 2015). However, abundance of information comes with an increasing necessity for communication among those participating in this endeavor. To effectively conduct future studies, it becomes critical to discern which categorized cell types correspond with each other, and to utilize the entirety of information already available to us about different cell types.

Our Purpose

The goal of this wiki is to consolidate information from existing retinal neuron classifications and accomplish the following:

• To establish a complete and accurate list of retinal neuron types, including synonyms
• To provide information about each cell type, with links to the relevant literature
• To cross-reference with information about cell types generated by EyeWire and showcased in Cell Museum

Our Approach

Because there is so much information about so many cell types being generated, a single person cannot document it all. We believe that the wiki must be developed collectively by multiple contributors from the research community. This approach will also keep the information current as new research is published. We hope that this wiki will act as a useful resource for those conducting research in the retina and the rest of the visual system, and help us all in a collective effort to make a complete catalog of murine retinal neurons.

If you are interested in contributing, please create an account with us create an account and begin editing. Existing (and suggested) pages are listed below. If you have never edited a wiki before and require assistance, please email us and we will be glad to help.

v t e Retinal Neuron Types Photoreceptors Rods Cones Horizontal Cell fill me in! Amacrine Cell Starburst Amacrine Cell Bipolar Cell OFF BC1 BC2 BC3a BC3b BC4 ON BC5t BC5o BC5i XBC BC6 BC7 BC8 BC9 RBC Ganglion Cell On-Off Direction-Selective DRD4 TRHR On Direction Selective SPIG1 Off Direction Selective J-RGC Alpha ON sustained write something! ON transient fill me in! OFF sustained fill me in! OFF transient CB2 W7a Local Edge Detectors W3 Intrinsically Photosensitive (ipRGC) M1 M2