Ganglion Cell

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Two different views (side and bottom) of a type of retinal ganglion cell called W3.

Ganglion cells are the output cells of the retina. Their axons leave the eye and travel through the optic nerve to the brain, sending the processed visual stimulus to the lateral geniculate nucleus, forming synapses onto neurons that project to the primary visual cortex, where the stimulus can be further interpreted.


A retinal ganglion cell (RGC) is a type of neuron located near the inner surface (the ganglion cell layer) of the retina of the eye. It receives visual information from photoreceptors via two intermediate neuron types: bipolar cells and amacrine cells. Retinal ganglion cells collectively transmit image-forming and non-image forming visual information from the retina to several regions in the thalamus, hypothalamus, and mesencephalon, or midbrain.

Retinal ganglion cells vary significantly in terms of their size, connections, and responses to visual stimulation but they all share the defining property of having a long axon that extends into the brain. These axons form the optic nerve, optic chiasm, and optic tract. A small percentage of retinal ganglion cells contribute little or nothing to vision, but are themselves photosensitive; their axons form the retinohypothalamic tract and contribute to circadian rhythms and pupillary light reflex, the resizing of the pupil.


Ganglion cells are the final output neurons of the vertebrate retina. The ganglion cell collects the electrical messages concerning the visual signal from the two layers of nerve cells preceding it in the retinal wiring scheme. A great deal of preprocessing has been accomplished by the neurons of the vertical pathways (photoreceptor to bipolar to ganglion cell chain), and by the lateral pathways (photoreceptor to horizontal cell to bipolar to amacrine to ganglion cell chain) before presentation to the ganglion cell and so it represents the ultimate signaller to the brain of retinal information. Ganglion cells are larger on average than most preceding retinal interneurons and have large diameter axons capable of passing the electrical signal, in the form of transient spike trains, to the retinal recipient areas of the brain many millimeters or centimeters distant from the retina. The optic nerve collects all the axons of the ganglion cells and this bundle of more than a million fibers (in man at least) then passes information to the next relay station in the brain for sorting and integrating into further information processing channels.

Visual response properties

Cellular biophysics







Cajal's drawing of ganglion cells of the frog retina
File:Ox and dog ganglion cells.jpeg
Cajal's drawing of ganglion cells of ox and dog retinas

Cajal in his monumental work on Golgi staining of the vertebrate retina was able to classify many different varieties of ganglion cell based on form (dendritic morphology), extent (cell body and dendritic tree size), and number of sublayers in which they arborize (stratification levels in the inner plexiform layer). He considered the retina to be remarkably uniform across all vertebrates differing only in respect to rod and cone specializations for the visual sense of the animal. Looking at Cajals (1892) drawings of dog ganglion cells as compared frog ganglion cell for example the former seem simpler in form than the latter cells (see Figs. 1 and 2 above) but we actually now know that there is a common evolutionary path taken by different ganglion cell types so that different morphological and functional classes are similar throughout the species. For example the large ganglion cells, with open radiate branching patterns, process fast, transient impulse trains and in all vertebrate retinas are concerned with motion detection and alerting the animal to threatening, moving visual imagery. While small bushy ganglion cell types are concerned with processing small stationary, fine detail in tonically activated messages in all species.

In the forties, Polyak (1941) produced a phenomenal description of the Golgi-impregnated neurons of the primate retina and therein he gave us a good classification of ganglion cell types (see chapter on Midget Pathways). So by the sixties we had a fairly extensive description and classification of the ganglion cells in mammalian and monkey retinas but all the data was based on vertical sections of stained ganglion cells (Cajal, 1892; Polyak, 1941; Brown and Major, 1966; Leicester and Stone, 1967; Boycott and Dowling, 1969; Shkolnik-Yarros, 1971). The advent of a technique to perform Golgi staining on wholemount retinas allowed a reinterpretation of many of the earlier classifications, because now we could see the entire dendritic tree of a ganglion cell.

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