Difference between revisions of "DRD4-RGC"

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(Created page with "DRD4-DSGCs are On-Off direction selective ganglion cells that respond to global posterior motion (backward motion in relation to the world). These cells were discovered in tra...")
 
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DRD4-DSGCs are On-Off direction selective ganglion cells that respond to global posterior motion (backward motion in relation to the world). These cells were discovered in transgenic mice that express GFP under the control of the dopamine receptor 4 promoter (DRD4-EGFP). Interestingly, the GFP positive RGCs in this mouse line all have characteristics of On-Off DSGCs, and exclusively prefer posterior motion.  
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[[File:Drd4_huberman_2009.PNG|thumb|right|400px|On-Off DSGC from DRD4-GFP mouse filled with biocytin. White arrow shows the axon, yellow arrows show "looping" arborizations characteristic of mouse DSGCs. Image adapted from Huberman et al., 2009]]
[[File:Drd4_huberman_2009.PNG|300px|none|On-Off DSGC from DRD4-GFP mouse filled with biocytin. White arrow shows the axon, yellow arrows show "looping" arborizations characteristic of mouse DSGCs. Image adapted from Huberman et al., 2009]]
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DRD4-DSGCs are On-Off direction selective ganglion cells that respond to global posterior motion (backward motion in relation to the world). These cells were discovered in transgenic mice that express GFP under the control of the dopamine receptor 4 promoter (DRD4-EGFP). Interestingly, the GFP positive RGCs in this mouse line all have characteristics of On-Off DSGCs, and exclusively prefer posterior motion.

Revision as of 19:13, 17 September 2015

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On-Off DSGC from DRD4-GFP mouse filled with biocytin. White arrow shows the axon, yellow arrows show "looping" arborizations characteristic of mouse DSGCs. Image adapted from Huberman et al., 2009

DRD4-DSGCs are On-Off direction selective ganglion cells that respond to global posterior motion (backward motion in relation to the world). These cells were discovered in transgenic mice that express GFP under the control of the dopamine receptor 4 promoter (DRD4-EGFP). Interestingly, the GFP positive RGCs in this mouse line all have characteristics of On-Off DSGCs, and exclusively prefer posterior motion.