Difference between revisions of "CB2-RGC"
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| − | Retinal ganglion cells that express [https://en.wikipedia.org/wiki/Calretinin calretinin], | + | Retinal ganglion cells that express [https://en.wikipedia.org/wiki/Calretinin calretinin], or 29 kDa calbindin, are known as '''CB2-GRCs'''. They are a type of transient OFF-alpha RGCs (tOFF-alphaRGC). Like all alpha cells, these RGCs are immunoreactive with SMI-32, an antibody that recognizes an antigen rich in alpha RGC neurofilaments. They possess large, spherical somas, and monostratify within the OFF sublamina of the [https://en.wikipedia.org/wiki/Inner_nuclear_layer inner nuclear layer] (IPL). Typical of cells that exhibit transient OFF-type physiological responses, they depolarize and spike briefly at the offset of a flash (Huberman et al., 2008). Their axons project exclusively to the superior colliculus (SC) and the dorsal lateral geniculate nucleus (dLGN). |
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==Molecular definition== | ==Molecular definition== | ||
Revision as of 16:00, 25 September 2015
Retinal ganglion cells that express calretinin, or 29 kDa calbindin, are known as CB2-GRCs. They are a type of transient OFF-alpha RGCs (tOFF-alphaRGC). Like all alpha cells, these RGCs are immunoreactive with SMI-32, an antibody that recognizes an antigen rich in alpha RGC neurofilaments. They possess large, spherical somas, and monostratify within the OFF sublamina of the inner nuclear layer (IPL). Typical of cells that exhibit transient OFF-type physiological responses, they depolarize and spike briefly at the offset of a flash (Huberman et al., 2008). Their axons project exclusively to the superior colliculus (SC) and the dorsal lateral geniculate nucleus (dLGN).
Contents
Molecular definition
Physiology
Anatomy
Dendritic Morphology
Retinal Input
Central Projections
Behavioral Output
History
References
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