Translations:On-Off Direction-Selective Ganglion Cell/11/en
Molecules
As described above, ON/OFF DS ganglion cells can be divided into 4 subtypes differing in their directional preference, ventral, dorsal, nasal, or temporal. Recent research has identified markers for distinguishing between the different subtypes, and for separating ON/OFF DSGCs from other retinal ganglion cells. These markers are independent of experience, and suggest a method for how these cells obtain different inputs.
Recent research has lead to the development of transgenic mouse lines that selectively mark ON/OFF DSGCs that prefer ventral or nasal motion and another line that marks ventral and dorsal preferring DSGCs. These lines were used to identify cell surface molecules (including Cadherin 6, CollagenXXV1, and Matrix metalloprotease 17), that allow each of the four types of ON/OFF DSGCs to be differentiated. A neuropeptide, CART (cocaine and amphetamine regulated transcript) has been found to differentiate ON/OFF DSGCs from all other retinal ganglion cells. Strikingly, these patterns of molecular differentiation occur before animal eye-opening, and demonstrate that these differences are experience-independent. Therefore, the molecular differences may help to explain the differing functionality between subtypes. [1]
Models
The firing pattern of On-Off Direction-Selective Ganglion cells is time-dependent and is supported by the Reichardt- Hassenstain model, which detects spatiotemporal correlation between two adjacent cells [2].- ↑ J. N. Kay et al. (2011) Retinal ganglion cells with distinct directional preferences differ in molecular identity, structure, and central projections. J. Neurosci. 31 (21): 7753-7762 doi: 10.1523/JNEUROSCI.0907-11.2011
- ↑ Cite error: Invalid
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