Difference between revisions of "BC2"
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'''Bipolar Cell Type 2 (BC2)''' are one of five OFF bipolar cells in the retina. They stratify in the OFF sublamina in the inner plexiform layer (IPL). BC2s are in contact with at least one or two cone pedicles, and They can be distinguished from other bipolar cells with their expression of [https://en.wikipedia.org/wiki/Recoverin recoverin] and a type II [https://en.wikipedia.org/wiki/Cadherin cadherin], [https://en.wikipedia.org/wiki/CDH8 cdh8] (Havercamp et al., 2003, Duan et al., 2014). | '''Bipolar Cell Type 2 (BC2)''' are one of five OFF bipolar cells in the retina. They stratify in the OFF sublamina in the inner plexiform layer (IPL). BC2s are in contact with at least one or two cone pedicles, and They can be distinguished from other bipolar cells with their expression of [https://en.wikipedia.org/wiki/Recoverin recoverin] and a type II [https://en.wikipedia.org/wiki/Cadherin cadherin], [https://en.wikipedia.org/wiki/CDH8 cdh8] (Havercamp et al., 2003, Duan et al., 2014). | ||
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==Molecular Definition== | ==Molecular Definition== | ||
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[[File:Cb2gfp_huberman2008.PNG|thumb|right|400px|GFP positive cells in whole mount CB2-GFP mouse retina. A. whole mount retina. Scale = 500um B. GFP positive cells. C. Alpha RGCs are immunpositive to SMI-32 cells. D. GFP positive cells are all SMI-32 positive. CB2-RGCs appear to be alpha type RGCs. scale = 125um. E. GFP positive cells in the GCL (CB2-RGCs) and INL (amacrine cells). Scale = 100um. Image adapted from Huberman et al., 2008]] | [[File:Cb2gfp_huberman2008.PNG|thumb|right|400px|GFP positive cells in whole mount CB2-GFP mouse retina. A. whole mount retina. Scale = 500um B. GFP positive cells. C. Alpha RGCs are immunpositive to SMI-32 cells. D. GFP positive cells are all SMI-32 positive. CB2-RGCs appear to be alpha type RGCs. scale = 125um. E. GFP positive cells in the GCL (CB2-RGCs) and INL (amacrine cells). Scale = 100um. Image adapted from Huberman et al., 2008]] | ||
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==Physiology== | ==Physiology== |
Revision as of 23:12, 29 September 2015
Bipolar Cell Type 2 (BC2) are one of five OFF bipolar cells in the retina. They stratify in the OFF sublamina in the inner plexiform layer (IPL). BC2s are in contact with at least one or two cone pedicles, and They can be distinguished from other bipolar cells with their expression of recoverin and a type II cadherin, cdh8 (Havercamp et al., 2003, Duan et al., 2014).
Contents
Molecular Definition
There are several markers and transgenes that can be used to label BC2s, although not all of them are selective.
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Physiology
[[File:Cb2physio_huberman2008.PNG|thumb|500px|none|Physiological responses of CB2-RGCs to visual stimuli. A. Membrane potential response shows spike at offset of flash. B. Average subthreshold flash response of seven cells (gray), and average flash response of two example cells (blue, red). Image adapted from Huberman et al., 2
Anatomy
Dendritic Morphology
Retinal Input
Central Projections
Development
History
References
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